| Arsenal | Pablo Mari | Ankle Injury |
| Arsenal | Nelson, Reiss | Knee Injury |
| Arsenal | Chambers, C | Knee Injury |
| Arsenal | Martinelli, G | Knee Injury |
| Arsenal | Sokratis | Calf Injury |
| Arsenal | Partey | Knock |
| A Villa | Heaton | ACL Injury |
| A Villa | Traore, B | Thigh Injury |
| A Villa | Wesley Moraes | ACL Injury |
| Brighton | March | Ankle Sprain |
| Brighton | Trossard | Adductor Injury |
| Brighton | Izquierdo, J H | Knee Injury |
| Brighton | Andone, F | Knee Injury |
| Brighton | Izquierdo, J H | Knock |
| Burnley | Cork | Ankle Injury |
| Burnley | Bardsley | Knock |
| Burnley | Pieters | Calf Injury |
| Burnley | Stephens | Knock |
| Chelsea | Gilmour, B | Knee Injury |
| Chelsea | Arrizabalaga | Shoulder Injury |
| Chelsea | Pulisic | Thigh Injury |
| Chelsea | Havertz | Covid-19 |
| Chelsea | Kovačić | Foot Injury |
| C Palace | Mitchell, Tyrick | Knock |
| C Palace | Ward, Joel | Groin Strain |
| C Palace | Milivojević | Red Card Ban |
| C Palace | Wickham | Knock |
| C Palace | Ferguson, Nathan | Knee Injury |
| C Palace | Hennessey | Knock |
| Everton | Delph | Knock |
| Everton | Gbamin | Achilles Injury |
| Fulham | Tete, K | Calf Injury |
| Fulham | Lemina | Knock |
| Fulham | Seri, J | Fatigue |
| Fulham | Kongolo | Broken Foot |
| Fulham | Onomah | Knock |
| Leeds | Shackleton | Knock |
| Leeds | Rodrigo, M | Covid-19 |
| Leeds | Phillips, Kalvin | Shoulder Injury |
| Leeds | Berardi, G | ACL Injury |
| Leeds | Forshaw | Groin Injury |
| Leeds | Llorente, D | Muscle Injury |
| Leicester | Ricardo Pereira | Knee Injury |
| Leicester | Castagne | Thigh Injury |
| Leicester | Söyüncü | Groin Injury |
| Leicester | Ndidi | Tight Groin |
| Leicester | Amartey | Thigh Injury |
| Leicester | Fofana, W | Knee Injury |
| Liverpool | Thiago Alcántara | Knee Injury |
| Liverpool | Fabinho, T | Thigh Injury |
| Liverpool | Oxlade Chamberlain | Knee Injury |
| Liverpool | van Dijk, V | Knee Injury |
| Liverpool | Arnold, T | Calf Injury |
| Man City | Mendy, B | Muscle Injury |
| Man City | Fernandinho | Leg Injury |
| Man City | Agüero | Thigh Injury |
| Man Utd | Bailly, E | Knock |
| Man Utd | Lingard | Knock |
| Man Utd | Alex Telles | Covid-19 |
| Man Utd | Greenwood, M | Knock |
| Man Utd | Jones, Phil | Knee Injury |
| Man Utd | Romero, Sergio | Knock |
| Man Utd | Shaw, L | Thigh Injury |
| Man Utd | Rashford | Shoulder Injury |
| Millwall | Zohore | Calf Injury |
| Newcastle | Shelvey | Groin Injury |
| Newcastle | Dúbravka | Ankle Injury |
| Newcastle | Gayle, D | Knee Injury |
| Newcastle | Ritchie, Matt | Shoulder Injury |
| Newcastle | Fraser, R | Thigh Injury |
| Newcastle | Wilson, Callum | Thigh Injury |
| Sheff Utd | Fleck | Lower Back Injury |
| Sheff Utd | O’Connell, Jack | Knee Injury |
| Sheff Utd | Mousset | Ankle Injury |
| Sheff Utd | Moore, Si | Broken Finger |
| Southmptn | Smallbone | Thigh Injury |
| Southmptn | Vokins | Knock |
| Southmptn | Bertrand | Thigh Injury |
| Southmptn | Ward-Prowse | Hamstring Injury |
| Southmptn | Ings | Knee Injury |
| Southmptn | Valery, Y | Muscle Injury |
| Tottenham | Lamela | Calf Injury |
| Tottenham | Ndombèlé | Foot Injury |
| Tottenham | Bergwijn | Knock |
| Tottenham | Tanganga | Thigh Injury |
| West Brom | Robson Kanu | Elbow Injury |
| West Brom | Ivanović, B | Covid-19 |
| West Brom | Matheus Pereira, (1996) | Covid-19 |
| West Brom | Field, S | Knee Injury |
| West Ham | Noble, M | Chest Injury |
| West Ham | Ogbonna | Groin Injury |
| West Ham | Antonio, M | Thigh Injury |
| Wolves | Jonny | Knee Injury |